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Xenical

XENICAL is available as a dark-blue, hard-gelatin capsule, with light-blue imprinting. Each capsule contains 120 mg of the active ingredient orlistat.

HOW DOES XENICAL WORK?

XENICAL does not act centrally on the brain to reduce appetite. Its action takes place in the lumen of the stomach and absorption of the drug into the blood is minimal. In contradistinction, most other weight loss medicines act on specific areas of the brain to reduce appetite. You eat less, you lose weight - but at a price. In order to get to the brain, these pills must enter the blood stream. Therefore, they may have systemic side effects (central nervous system and cardiovascular) and are indicated only for short-term use. But, most important, these pills do little if anything to help people change their eating habits or lifestyles. Therefore, when they stop taking them, the weight is quickly regained.

XENICAL, on the other hand, is a reversible inhibitor of lipases made in the stomach and pancreas. Lipases are enzymes that break down fat. After we eat a fatty meal (such as meat) fats reach the stomach in a form called triglycerides. Triglycerides cannot be absorbed into the blood unless lipases break them down into compounds called fatty acids. XENICAL prevents this breakdown and the undigested triglycerides are excreted into the stool. The resulting decrease in caloric intake can have a positive effect on weight control.

HOW MUCH WEIGHT CAN I LOSE WITH XENICAL?

There is no clear-cut amount of weight that can be lost when taking XENICAL. Remember, in order for XENICAL to work optimally you must restrict your fat intake and take exercise. If you are committed to your weight loss program there is essentially no limit as to how much weight you can loose. Nonetheless, weight loss should be gradual and always be done safely. While it is important that you decrease you fat intake it is equally as important that you eat healthy and insure you obtain all essential nutrients each and every day. Keep in mind that even a small amount of weight loss can reward you with a big gain in your health. A loss of 5 to 10% of your current weight can result in a significant reduction of risk for disease.

CLINICAL EFFICACY STUDIES:

Pooled data from multiple trials indicated that weight loss averaged 12.4 lbs. to 13.4 lbs. in patients taking XENICAL. Overall 57% of treated patients lost over 5% of their base-line body weight. Those on XENICAL showed a decrease in total blood cholesterol and LDL cholesterol (low density cholesterol). This form of cholesterol acts to promote the deposition of fatty plaques along the walls of arteries. There was a concomitant increase in HDL cholesterol (high density cholesterol). This form of cholesterol acts to inhibit the deposition of fatty plaques along the walls of arteries. In international clinical studies with thousands of patients, most individuals using XENICAL lost, on average, 10% of their initial body weight over a 6-8 month period.

WHO SHOULD TAKE XENICAL?

XENICAL is a serious weight loss medication, indicated only for those who are truly obese (obesity is defined as having an initial body mass index greater than or equal to 30 kg/m2 or 27 kg/m2 in the presence of other risk factors such as hypertension, diabetes or increased serum cholesterol). The initial body mass index is calculated utilizing the patient’s height and weight. Therefore it is not generally recommended that it be used as a “summer” medication for transient weight loss. It is most commonly recommended that it be prescribed for those who are willing to make serious permanent changes in their eating and exercise habits